Grand Medical Group

About us

Grand Medical Group AG is a group of pharmaceutical companies specialized in the development, production, registration and introduction into medical practice of modern innovative products based on organic, synthetic and herbal compounds.

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10 Kornmarkt Street, CH - 6004 Luzern, Switzerland

+41 415880810

Each ampoule with solution for injection contains 1 g Levocarnitine, ampoules No5, Bottle 120 ml, each milliliter of solution contains 400 mg of L-Carnitine


ATC Code: A16AA01, Amino acids and derivatives Levocarnitine is present as a natural constituent in animal tissues, micro-organisms and plants. In man the physiological metabolic requirements are met both by the consumption of food containing carnitine and the endogenous synthesis in the liver and kidneys from lysine with methionine serving as the methyl donor. Only the L-isomer is biologically active, playing an essential role in lipid metabolism as well as in the metabolism of ketone bodies as branched chain-amino-acids. Levocarnitine as a factor is necessary in the transport of long-chain fatty acids into the mitochondria – facilitating the oxidation of fatty acids rather than their incorporation into triglycerides. By releasing CoA from its thioesters, through the action of CoA; carnitine acetyl transferase, levocarnitine also enhances the metabolic ?ux in the Kreb’s cycle; with the same mechanism it stimulates the activity of pyruvate dehydrogenase and in skeletal muscle, the oxidation of branched chain-amino acids. Levocarnitine is thus involved, directly or indirectly in several pathways so that its availability should be an important factor controlling not only the oxidative utilization of fatty acids and ketone bodies but also that of glucose and some amino acids to provide the organism with energy and support normal metabolism processes. 


ALMIBA is indicated for the treatment of primary and secondary carnitine de?ciency in adults, children, infants and neonates.

ALMIBA is indicated in the treatment of primary systemic carnitine de?ciency. In the reported cases, the clinical presentation consisted of recurrent episodes of Reye?like encephalopathy, hypoketotic hypoglycemia, and/or cardiomyopathy. Associated symptoms included hypotonia, muscle weakness and failure to thrive.

ALMIBA is also indicated for acute and chronic treatment of patients with an inborn error of metabolism which results in a secondary carnitine de?ciency. Also ALMIBA is also indicated for the therapy of carnitine de?ciency in haemodialysis patients.

Secondary carnitine de?ciency should be suspected in long-term haemodialysis patients who have the following conditions:

1. Severe and persistent muscle cramps and/or hypotensive episodes during dialysis.
2. Lack of energy causing a significant negative e?ect on the quality of life.
3. Skeletal muscle weakness and/or myopathy.
4. Cardiomyopathy.
5. Anaemia of uraemia unresponsive to or requiring large doses of erythropoietin.
6. Muscle mass loss caused by malnutrition.