NIKSON®

|Each vial contains cefotaxime sodium equivalent to 1 g of cefotaxime, powder for solution for injection in vial № 1 with solvent 4 ml in ampoule № 1

 

PHARMACOLOGIC PROPERTIES

ATC code: J01D A10, Beta-lactam antibiotics, cephalosporins.

Cefotaxime is a third generation broad spectrum bactericidal cephalosporin antibiotic. The bactericidal properties are due to the inhibitory effect of cefotaxime on bacterial cell wall synthesis.

Unlike β-lactams such as penicillin and amoxicillin, which are highly susceptible to degradation by β-lactamase enzymes (produced, for example, nearly universally by S. aureus), cefotaxime boasts the additional benefit of resistance to β-lactamase degradation due to the structural configuration of the cefotaxime molecule. The syn-configuration of the methoxyimino moiety confers stability against β-lactamases. Consequently, the spectrum of activity is broadened to include several β-lactamase-producing organisms (which would otherwise be resistant to β-lactam antibiotics).

 

THERAPEUTIC INDICATIONS

  1. Cefotaxime is indicated in the treatment of serious infections, either before the infecting organism has been identified or when caused by bacteria of established sensitivity, including
  • Osteomyelitis,
  • Septicaemia,
  • Bacterial endocarditis,
  • Meningitis, and
  • Peritonitis. and other serious bacterial infections suitable for parenteral antibiotic therapy.

   2. Cefotaxime may be used for pre-operative prophylaxis in patients undergoing surgical procedures that may be classified as contaminated or potentially so.

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